How many people stop using GLP-1 drugs and why is not an unreported phenomenon, but I think it is under-reported in mainstream news media coverage in light of the seemingly non-stop promotion of the drugs.
I'm very curious what's causing the abdominal pain, like what is happening physiologically in nearly two-thirds of people in that NIH study who reported pain. That's crazy high. And a ~4% risk of pancreatitis would definitely make me think twice.
Anecdotally, at Healthy Hearing, we've seen an increase in search traffic to our page on drugs that cause hearing loss because of the search term "ozempic deafness."
I have been on Ozempic and now Mounjaro. I have been dizzy, lightheaded, have shortness of breath and have never felt more fatigued in my life. All of this in the last month or so. Just had bloodwork done and my kidney function is very concerning, my thyroid levels are all over the place despite having been in the normal range with synthroid for years and it seems I’m extremely anemic. But hey, I lost weight and my A1C is now under the pre-diabetes level.
From my limited research looks like statins’ discontinuation rate is about 50%. Same for many other commonly prescribed medications. They just like to single out GLP1 agonists because of weight bias.
My crystal ball isn't good enough to project that, and I'm not sure I'd trust anyone else's. They haven't done it till they've done it - with strong evidence in large numbers of people over a considerable period of time.
I'm very curious what's causing the abdominal pain, like what is happening physiologically in nearly two-thirds of people in that NIH study who reported pain. That's crazy high. And a ~4% risk of pancreatitis would definitely make me think twice.
Anecdotally, at Healthy Hearing, we've seen an increase in search traffic to our page on drugs that cause hearing loss because of the search term "ozempic deafness."
“Financial reasons” and “side effects” sound like very plausible reasons for the high discontinuation rates.
Uncovering rare and/or long term side effects that would be undetected during the course of an RCT, is good use of registry data such as this.
I have been on Ozempic and now Mounjaro. I have been dizzy, lightheaded, have shortness of breath and have never felt more fatigued in my life. All of this in the last month or so. Just had bloodwork done and my kidney function is very concerning, my thyroid levels are all over the place despite having been in the normal range with synthroid for years and it seems I’m extremely anemic. But hey, I lost weight and my A1C is now under the pre-diabetes level.
Interesting data. How does the discontinuation rate compare to other drugs for chronic diseases such as the “Statins”?
From my limited research looks like statins’ discontinuation rate is about 50%. Same for many other commonly prescribed medications. They just like to single out GLP1 agonists because of weight bias.
A high attrition rate is not the same as not using a drug. Most drugs have a compliance range just north of 50% which GLP1s also represent well.
Won't next generations of these drugs have a better efficacy/safety profile?
My crystal ball isn't good enough to project that, and I'm not sure I'd trust anyone else's. They haven't done it till they've done it - with strong evidence in large numbers of people over a considerable period of time.